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PUBLICATIONS

Peer-reviewed and Preprints

Pregnancy Reduces Il33+ Hybrid Progenitor Accumulation in the Aged Mammary Gland. BioRxiv, Aug 6, 2024

DOI: https://doi.org/10.1101/2024.08.01.606240

Andrew Olander, Cynthia M Ramirez, Veronica Haro Acosta, Paloma Medina, Sara Kaushik, Vanessa D Jonsson, Shaheen S Sikandar. 

Sikandar Lab member

LMO2 is critical for early metastatic events in breast cancer. Science Advances, Nov 11, 2022. 
DOI: 10.1126/sciadv.abm3548
Press Release here

Sikandar SS*#, Antony J*, Gulati GS*, Fetter IJ, Kuo AH, Ho W HD, Haro-Acosta V, Das S, Steen CB, Pereira TA, Qian D, Beachy PA, Dirbas F, Red-Horse K, Rabbitts TH, Thiery JP, Newman AM, Clarke MF#.  #Co-corresponding author, *Co-first author, Sikandar lab member

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. Science 2022

DOI: 10.1126/science.abl4896

The Tabula Sapiens Consortium (Including Sikandar SS)

Mesenchymal tumor cells drive adaptive resistance of Trp53-/- breast tumor cells to inactivated mutant Kras. Molecular Oncology Sep 2022

DOI: 10.1002/1878-0261.13220

Van Weele LJ,  Djomehri SI, Cai S, Antony J, Sikandar SS, Qian D, Ho WHD, West RB, Scheeren FA, Clarke MF

Introductions to the Community: Early-Career Researchers in the Time of COVID-19. Cell Stem Cell. 2020. 

DOI: 10.1016/j.stem.2020.10.008

Smith Q, McKinley KL, Chan CJ, Sikandar S, Xiang Y, Passaro D.

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse, Nature 2020. 

DOI: 10.1038/s41586-020-2496-1

Tabula Muris Consortium (Including Sikandar SS)

Single-cell transcriptional diversity is a hallmark of developmental potential. Science 2020 

DOI: 10.1126/science.aax0249

Gulati GS*, Sikandar SS*, Wesche DJ, Manjunath A, Bharadwaj A, Berger MJ, Ilagan F, Kuo AH, Hsieh RW, Cai S, Zabala M, Scheeren FA, Lobo NA, Qian D, Yu FB, Dirbas FM, Clarke MF, Newman AM. *Co-first authors (Recommended by Faculty of 1000)

Single cell transcriptomics of 20 mouse organs creates a Tabula Muris. Nature. 2018 

DOI: 10.1038/s41586-018-0590-4

Tabula Muris Consortium (Including Sikandar SS)

Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis. Nature Communications 2017.  

DOI: 10.1038/s41467-017-01666-2

Sikandar SS, Kuo AH, Kalisky T, Cai S, Zabala M, Hsieh RW, Lobo NA, Scheeren FA, Sim S, Qian D, Dirbas FM, Somlo G, Quake SR, Clarke MF. (Recommended by Faculty of 1000)

Quiescent Bcl11b high stem cell population is required for maintenance of the mammary gland. Cell Stem Cell, 2017

DOI: 10.1016/j.stem.2016.11.007

Cai S, Kalisky T, Sahoo D, Dalerba P, Feng W, Lin Y, Qian D, Kong A, Yu J, Wang F, Chen E, Scheeren F, Kuo A, Sikandar S, Hismori S, Van Weele L, Heiser D, Sim S, Lam J, Quake SR, Clarke MF.

miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway. Elife. 2014. '

DOI: 10.7554/eLife.01977.

Isobe T, Hisamori S, Hogan DJ, Zabala M, Hendrickson DG, Dalerba P, Cai S, Scheeren F, Kuo AH, Sikandar S, Lam JS, Qian D, Dirbas FM, Somlo G, Lao K, Brown PO, Clarke MF, Shimono Y.

A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis. Nat Cell Biol. 2014 Dec. DOI:10.1038/ncb3058

Scheeren FA, Kuo AH, van Weele LJ, Cai S, Glykofridis I, Sikandar S, Zabala M, Qian D, Lam JS, Johnston D, Volkmer JP, Sahoo D, van de Rijn M, Dirbas FM,Somlo G, Kalisky T, Rothenberg ME, Quake SR, Clarke MF.

USP16 contributes to somatic stem cell defects in Down’s Syndrome. Nature. Sep 2013.

DOI: 10.1038/nature12530

Adorno M, Sikandar S, Mitra S, Kuo A, Robilant BN, Haro-Acosta V, Ouadah Y, Quarta M, Rodriguez J, Qian D, Reddy VM, Cheshier S, Garner C, Clarke MF.

mir-23a promotes transition from indolent to invasive colorectal cancer. Cancer Discovery June 2012 Jun. DOI: 10.1158/2159-8290.CD-11-0267

Jahid S, Sun J, Edwards RA, Dizon D, Panarelli NC, Milsom JW, Sikandar S, Gümüs ZH, Lipkin SM.

The Class I HDAC Inhibitor MGCD0103 induces cell cycle arrest and apoptosis in colon cancer initiating cells by upregulating Dickkopf-1 and non-canonical WNT signaling. Oncotarget 2010 Nov.

DOI:10.18632/oncotarget.101001

Sikandar S, Dizon D, Shen X, Li Z, Besterman J, Lipkin SM.

NOTCH signaling is required for colon cancer initiating cell tumor formation, self-renewal and repression of secretory cell lineage differentiation. Cancer Research 2010 Feb.

DOI: 10.1158/0008-5472.CAN-09-2557

Sikandar S, Pate K, Andersen S, Dizon D, Edwards R, Waterman ML, Lipkin SM.

Impaired placental trophoblast lineage differentiation in Alkbh1-/-mice. *Co-first authors. Developmental Dynamics. 2008 Feb. 2008 Feb.

DOI: 10.1002/dvdy.21418

Pan Z*, Sikandar S*, Witherspoon M, Dizon D, Nguyen T, Benirschke K, Wiley C, Vrana P, Lipkin SM. *Co-first authors

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